24. 1. 2009 - 28. 1. 2009
PREDICTION OF RESPONSE TO BUPROPION TREATMENT - THE EARLY CHANGE OF PREFRONTAL QEEG CORDANCE. OPEN LABEL STUDY
M. Bares1,2, M. Brunovsky1,2, T. Novak1,2, M. Kopecek1,2,3, P. Stopkova1,2, P. Sos1,2, C. Höschl1,2
1Prague Psychiatric Centre, 2The Department of Psychiatry and Medical Psychology, 3rd Faculty of Medicine, Charles University, Prague, Czech Republic, 3Center for Excellence for Research & Treatment Bipolar Disorder, Department of Psychiatry, University of North Carolina at Chapel Hill, Chapell Hill, USA
Aims: Previous studies demonstrated predictive effect of reduction of prefrontal cordance for non-resistant outpatients or resistant inpatients treated by various antidepressants or venlafaxine. The aim of the present study was to examine whether the reduction of theta prefrontal QEEG cordance value after 1 week of bupropion administration is associated with response to 4 weeks treatment in patients with resistant depressive disorder. We extended our previous pilot data.
Methods: We analyzed 18 inpatients, who finished 4-week treatment with venlafaxine. EEG data were monitored at baseline and after 1 week of treatment. QEEG cordance was computed at 3 frontal electrodes in theta frequency band. Depressive symptoms were assessed using Montgomery-Åsberg Depression Rating Scale (MADRS).
Results: Nine of 11 responders (reduction of MADRS ≥50%) and no one of 7 non-responders decreased prefrontal QEEG cordance value after the first week of treatment. Positive and negative predictive value (PPV, NPV) of cordance reduction for response to treatment was 1.0 (95% CI, 0.8-1.0) and 0.78 (95% CI, 0.57-0.78), respectively.
Conclusions: Based on our results, the prefrontal QEEG cordance might be helpful in the prediction of the response to bupropion treatment in resistant patients.
This study was supported by a grant from Internal Grant Agency of Ministry of Health of Czech Republic No. NR/9330-3 and a grant from Ministry of Health of Czech Republic MZ0PCP2005.